The basic premise isn’t clear for the first time reader – I haven’t read any other versions of this concept.

Here is what I got just now:
The MC is a psychic P.I – I’m not sure what a psychic P.I actually means. Does he use his powers to investigate cases? Does he only investigate cases related to people with psychic powers?

He needs to enter his own mind… Now this statement really threw me, the assumption is that a person is already in his own mind, how then does one enter that which he is already inside?
Perhaps, if the inciting incident was that another psychic took over his mind, he would now have to fight for control over it, but that wasn’t in the logline.

How can someone else infect a person’s consciousness? They could infect their mind or body, but consciousness is a state of being, it doesn’t make much sens that it can be infected. Also, infected how? How does this infection manifest itself? This may seem nit picky, but if you’re dealing with psychic powers, mind control and consciousness, you really need to get the terminology correct and logical so it makes sense across the board.

The sister is only mentioned last, how does she play into this? It feels like she was tacked on at the end to add a personal stake more than having been an integral part of the story.