Leonard and Sheldon avert a nuclear disaster, as Amy tries to cure Raj of his social anxiety around women, while Bernadette throws Howard a birthday to remember.

Sounds like this could be a really interesting and truly original screenplay!

As with Jan above me I think I agree that my concern is I don’t get from your logline the sense of what your movie will actually be about – its as though you’ve given a snapshot of characters and scenarios within your film rather than an idea of what the narrative content of your film would be, or the overarching theme.

That must be challenging with these multi story strand style screenplays – which can be so brilliant!

If there is an event that draws the characters together or forces them to go on some sort of journey you could focus in there…

“When an oddball group of party guests realise nuclear disaster could be imminent they must try to overcome their personal quirks to work together and avert disaster”

Apologies if that’s not at all your film. Perhaps the main goal is simply to make sure Howard is oblivious to the going on around him and has a great birthday…

What ever the main goal of your group or protagonist that’s what I want to hear about!

(Your premise makes me think of death at a funeral – I hope that tone is what you have in mind, I love it!)

Best of luck