After acceptance into a new gene-altering program, a nerdy, popular eSports gamer undergoes a risky, unknown side-effects procedure to become a NFL quarterback hoping to win a Super Bowl.

I have all the same questions as Trix.

I like the premise. Weedy gamer undergoes experimental treatment to become buff – like a Captain America type thing.

He wouldn’t just get accepted as a quarterback though. This logline makes it sound as though the treatment MAKES him a quarterback. Sure that’s not the case but could do with clarifying.

I think you can trim this down a lot and then add some more stuff to remove questions:

“After undergoing a risky procedure to “pro-athlete” his body, a nerdy eSports gamer must…”

Then tell us what he is going to do next.

Become quarterback and fall in love with a cheerleader, only for a cheerleader to love him for his personality and he still gets her when he goes back to normal? Cliche perhaps? Body swap type things usually are a little bit… everybody always ends up happy to go back to who they were in the end.

I think including “risky” is begging for an MPR. At the midpoint, we discover that the procedure….? something? I don’t know what. Maybe it’s only meant to be a temporary and he discovers that it’s potentially going to be permanent if he doesn’t do something he doesn’t want to do. Whatever message you’re trying to say “be happy with who you are” or “there’s no quick fix” etc, it’s worth using this to help with the MPR.