When her family unexpectedly comes back into her life after years of estrangement, a young woman must confront her past and the people who will never accept her for who she is.

I don't know if you need this, "after years of estrangement, "

Perhaps you'll like this. It gives me an idea that she's old enough to have life experience and (for me) adds an element of suspense.

A twenty-something must confront her past and the people who will never accept her for who she is when, after years of estrangement, family members come back into her life, one-by-one.

Overall it sounds great and i definitely think theres a great story there. I would just suggest maybe add more detail to the character? Maybe "A troubled young woman" ? something like that :)