It is indeed an Odd Couple scenario. As you mention, the two characters do start out very incompatibly however the idea is that, over the course of the first episode, they come to understand each other and connect. However they are still very different people so conflict will be generated through their differing personalities and also through being young uni students trying to find themselves. From financial burdens to family expectations and their own dreams.
I hear what you are saying about desiring higher stakes etc. in the presence of the logline, however this will change from episode to episode, as will their personal challenges. Again, take a look at the premise for comedies like Broad City, Inbetweeners, Flight of the Concords. Self-contained episodes where there are some ongoing threads.