A wheelchair-bound girl must learn to use her physical abilities to save herself and friends from a pack of female zombies.

I think your concept is good, the logline, as expressed by Danzig does need a little work

I would say a movie about a woman learning to use her physical abilities seems weird, Maybe she searches youtube, "How to use Physical abilities" then goes to the library and checks out a book on learning physical abilities. After that maybe she takes a class, finally after learning to use her abilities in the third act she saves the day.

Instead, I would focus on what she actually must do.

This is just an example yours would be different:

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"When the zombie apocalypse lands smackdab in her small town, a wheelchair-bound radio aficionado and her friends must trek up the local mountain and send out a zombie-killing radio wave in order to save the world from the brain-eating freaks."

I think this is interesting, and definitely a new take on a zombie film.? I have four thoughts on it:

1. I have no idea where these zombies came from.? Is this a zombie apocalypse?? A mishap at a lab?? Zombies from Comic-con that happen to be real?? It just seems out of the blue.? No issue with explaining what the wheel-chair bound girl is doing there.? Plenty of girls and disabilities happen, but, zombies don't really exist so ya might want some backstory.
2. Maybe phrase the logline so it includes an inciting incident.? What happens that leads up to this attack?? When a wheel-chair bound girl discovers that a group of zombies at Comic-con are real, she must use her physical abilities to save herself and her friends.
3. I'd like to know a bit more about the wheelchair-bound girl's mental state/personality with another adjective.? ?I'm guessing you're going for a character that first needs to believe she can do the things that she needs to do, before she can do them.? Maybe "When a despairing wheelchair-bound girl..."
4. I have no idea why the zombies being female is important enough to include in the logline, and it's kind of a weird choice.? I'm assuming you have an explanation for it?? It might come off as necrophilia or something :)