An? wheelchair-bound college girl must use her physical abilities and mental acumen to save her trapped friends from zombies who have surrounded their cottage.

I get this wheelchair-bound character it helps to ramp up the primal fear factor, but in horror movies remember evil is the star. That is what folks are paying to see. If you want a story where your wheelchair-bound character prevails e.g. ?girl must use her physical abilities and mental acumen to save? shoot for a Thriller or in this case Thriller-horror mashup.
Curious to know if you are going to rewrite based on the coverage you received.
If so, I would pay to see the following ?

• A murderous girl clique lures an easy target (wheelchair-bound girl) to their lake cabin kill zone but gets the shock of their life when they discover she teams up with their former victims (zombies) to turn the tables.
• A wheelchair-bound girl must escape from the observation deck of a quarantined Empire State Building during a blackout as hordes of zombies chew their way up the 102 floors.

Take care.

It's an interesting point - I thought it would be but a reader who saw my screenplay said, even with the added feature of the friends plotting to kill the wheelchair girl, the hook wasn't good enough.... it's hard for me to tell what would have been a better hook... I really want to tell an empowerment plot-based horror flick because I haven't seen that many produced lately...

It's a zombie flick with a twist - the main character is wheelchair-bound.

As the genre is well established and chock full of tropes, the trick is to find an appropriate twist - a wheelchair may be enough, but it's hard to tell.